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Molekul: Jurnal Ilmiah Kimia

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Published by Universitas Jenderal Soedirman

ISSN : 19079761 EISSN : 25030310 DOI : -

Core Subject : Science, Engineering,

Chemical Engineering, Chemistry & Bioengineering Chemistry

MOLEKUL is a peer-reviewed journal of chemistry published by the Department of Chemistry, Faculty of Mathematics and Natural Sciences, Jenderal Soedirman University, Indonesia. Publishing frequency 2 issues per year, on May and November. This Journal encompasses all branches of chemistry and its sub-disciplines including Pharmaceutical, Biological activities of Synthetic Drugs, Environmental Chemistry, Biochemistry, Polymer Chemistry, Petroleum Chemistry, and Agricultural Chemistry.

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Articles 12 Documents

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Search results for , issue "Vol 16, No 2 (2021)" : 12 Documents clear

Backmatter (Instruction for author and back cover) Amin Fatoni
Molekul Vol 16, No 2 (2021)
Publisher : Universitas Jenderal Soedirman

Backmatter (Instruction for author and back cover)

Chemical Sensor for Detection of Lead Levels in Herbal Medicine Ani Mulyasuryani; Yuniar Ponco Prananto; Elvian Eka Krisnaniningrum
Molekul Vol 16, No 2 (2021)
Publisher : Universitas Jenderal Soedirman

A new tube type Pb2+ sensor made from two types of mixtures, namely clay-PbI2 and chitosan-PbI2 were prepared. An electromotive force (EMF) with Ag/AgCl as the reference electrode was used as the output signal. The highest performance of the Pb2+ sensor from clay-PbI2 was obtained at Pb2+ solutions in HNO3 and pH 3 with sensor sensitivity of 20.67 mV/decade. The highest performance of the Pb2+ sensor from chitosan-PbI2 was obtained at Pb2+ solutions in demineralized water with sensor sensitivity of 32.49 mV / decade. Application of the two sensors on several commercial herbal samples resulted in an average recovery of 85.62% and 94.10% for sensor from chitosan-PbI2 and clay-PbI2, respectively

Antioxidant Activity and Total Phenol Extract of Kecombrang Flower, Stem and Leaves with Different Types of Solutions Siti Nuryanti; Nurul Latifasari; Rifda Naufalin; Rumpoko Wicaksono; Erminawati Erminawati
Molekul Vol 16, No 2 (2021)
Publisher : Universitas Jenderal Soedirman

Kecombrang (Etlingera elatior) is one of the spices which is quite widespread in Indonesia and has many uses. Kecombrang extract has the potential as an antioxidant and natural antimicrobial to extend the shelf life of food products. Extraction was carried out by multilevel maceration method with different types of solvents. This study aims to determine the effect of extraction on the bioactive components of flowers, stems and leaves of kecombrang in different types of solvents and determine the antioxidant activity and total phenols of each type of kecombrang plant extract.The results showed that extraction with distilled water produced the highest total phenol, antioxidant activity and yield on kecombrang leaves. The total phenol extracts of n-hexane leaves, leaves of ethyl acetate, and leaves of kecombrang distilled water were 19.116, 10.276, and 45.008 (mg TAE g db -1) respectively. The antioxidant activity value of flowers, stems and leaves of distilled water solvent kecombrang are 69.754, 72.648, and 78.003 (%) respectively. The yield for flowers, stems and leaves with distilled water solvent is 15.9; 16.6 and 32.95 (%) respectively.

The Hepatotoxic and Nephrotoxic Effects of Purwoceng (Pimpinella pruatjan Molk.) Roots Ethanol Extract Administration in Subchronic Dose Fitranto Arjadi; Nur Signa Aini Gumilas; Ika Murti Harini; Vitasari Indriani; Lantip Rujito
Molekul Vol 16, No 2 (2021)
Publisher : Universitas Jenderal Soedirman

Purwoceng (Pimpinella pruatjan Molk) is an original Indonesian herb which is known to have an aphrodisiac effect. The active compounds in Purwoceng potentially have hepatotoxic and nephrotoxic effects.This study was aimed to analyze the effect of subchronic administration of Purwoceng roots ethanol extract to Wistar Strain of Rattus norvegicus rats. The method of this subchronic toxicity study was an experimental post test only with control group design. Forty male Rattus norvegicus were randomly divided into four groups and get 28-days treatment. Group A as control received aquadest and 1% CMC (carboxymethyl cellulose), group B, C, and D were given Purwoceng roots ethanol extract of 42, 84, and 168 mg/KgBW/day and 1% CMC. Parameters tested were the levels of urea, creatinine, SGPT (serum glutamic pyruvic transaminase), SGOT(serum oxaloacetic pyruvic transaminase), kidney and hepar histopatology.The results showed a statistically significant for the liver histopathological in group B, creatinine, urea, and kidney histopathology in group C. Our study concluded that subchronic administration of Purwoceng (Pimpinella pruatjan Molk) roots ethanol extract could induce hepatotoxicity at the 42 mg/KgBW/day dose level and nephrotoxicity at the 84 mg/KgBW/day dose level.

Two Limonoids from The Seeds of Chisocheton Macrophyllus and Their Cytotoxic Activity Against Mcf-7 Breast Cancer Cells Intan Rahmayanti; Nurlelasari Nurlelasari; Desi Harneti; Rani Maharani; Darwati Darwati; Yoshihito Shiono; Unang Supratman
Molekul Vol 16, No 2 (2021)
Publisher : Universitas Jenderal Soedirman

Limonoids (tetranortriterpenoids) are triterpenoid compounds that lose four terminals in their structural framework. These compounds have a wide variety of structures and interesting activities including anti-inflammatory, anti-cancer, anti-tumor and anti-malarial properties. The purpose of this study was to find limonoid compounds from the Indonesian Chisocheton plant, and one of which is Chisocheton macrophyllus. The dried and powdered seeds of C. macrophyllus (4.5 kg) were extracted with methanol and partitioned successively with n-hexane, ethyl acetate and n-butanol. Evaporation of each extract resulted in the crude extracts of n-hexane (346.6 g), ethyl acetate (60.8 g) and n-butanol (14.6 g). The n-hexane fraction was subjected to a silica gel vacuum-liquid chromatography (VLC) column packed with silica gel 60 using gradient of n-hexane, ethyl acetate and methanol (10% stepwise) to afford thirteen fractions (A-M). Fraction F (4.4 g) was subjected to silica gel column chromatography using gradient of n-hexane and ethyl acetate (5% stepwise). Subfraction F5 (1.2 g) was chromatographed on a column of silica gel eluted with n-hexane: CH2Cl2: EtOAc (2:7.5:0.5) to give compound 1 (19.7 mg) and fraction H (1.8 g) was subjected to silica gel column chromatography using gradient of n-hexane and ethyl acetate (5% stepwise) as eluting solvent to give 2 (12.0 mg). Chemical structures of 1 and 2 were elucidated by spectroscopic methods and determined as 6α-acetoxyepoxyazadiradione (1) and Dysobinin(2). Dysobinin (2) showed weak cytotoxic activity against MCF-7 breast cancer cells with an IC50 value of 228.15 μM

Light-induced synthesis of micron-sized metallic silver in aqueous extract of Rivina humilis L. fruits and its interaction with Corptotermes curvignathus Salprima Yudha S; Aswin Falahudin; Morina Adfa; Irfan Gustian; Herlina Herlina
Molekul Vol 16, No 2 (2021)
Publisher : Universitas Jenderal Soedirman

The aqueous extract of Rivina humilis was suitable to reduce silver ions (Ag+) to form micron-sized metallic silver at room temperature and without any addition of external reducing agent or stabilizer compounds. The reduction process was assisted by light, indicated by the colour change of the reaction mixture and supported by the appearance of peak at 455 nm in spectrophotometric analysis when the reaction was carried out under room light. Based on transmission electron microscopy (TEM) analysis, the as-prepared metallic silver was in spherical form. The analysis results using particles size analyzer (PSA) show their particles distribution from micro to nano size (average size was 199 nm). The interaction behaviour of micron-sized metallic silver/extract solution with Corptotermes curvignathus termites shows that the silver gives small additional effects along with the activity of the extract.

Ab-Initio Computational Study : The Activation Energy Changes and Steric Effects In Peptide Synthesis Of Ac-AA-NH2 and Ac-AP-NH2 Pratiwi, Indah; Cahyono, Bambang; Siahaan, Parsaoran
Molekul Vol 16, No 2 (2021)
Publisher : Universitas Jenderal Soedirman

Ab-Initio computational method can be used for simulating reaction mechanisms, such as concerted reaction mechanism on peptide synthesis. The concerted reaction is one of many possible pathways on how peptide can be synthesized. The purpose of this study are probing the concerted reaction mechanism and comparing the steric effect to the reaction, given by different side-chain of alanine (A) and proline (P). Two dipeptides formed from alanine and proline were computed at HF-SCF/6-31G** theory level: Ac-AA-NH2Â and Ac-AP-NH2.Â The res.lts show the activation energy ofÂ Ac-AA-NH2Â Â and Ac-AP-NH2Â forming via concerted pathway are 167.541 kJ/molÂ and 161.044 kJ/mol, respectively.Â The steric difference in side-chain affects the dihedral angle of the structure, and also gives difference to the entropy value of reaction.

Determination of Cu and Pb concentrations based on urease activity inhibition of Durio zibethinus L. seeds Zusfahair, Zusfahair; Fatoni, Amin; Ningsih, Dian Riana; Riapanitra, Anung
Molekul Vol 16, No 2 (2021)
Publisher : Universitas Jenderal Soedirman

The determination of heavy metal concentrations has been carried out using sophisticated instruments, and therefore a simple and reliable alternative method is needed as a comparison. The study aimed to determine Cu and Pb concentration of standard solution using the urease activity inhibition method ofÂ Durio zibethinusÂ L.Â Â seeds.Â Â The research started with urease extraction fromÂ DurioÂ D.Â zibethinusÂ L.Â seeds. The activity of the obtained extract was determined using the Nessler method. The optimum substrate concentration was also determined. Urease activity inhibition was carried out using various metal solution concentrations, which continued by plotting a log graph of urea concentration vs. %inhibition. The obtained graph would then determine the metal concentration in a synthetic water sample.Â The data was then compared to the measurement, determined by the Atomic Absorption Spectrophotometry (AAS) method.Â Results of the study showed that the urease activity ofÂ D. zibethinusÂ L.seeds was 296.774 U/mL. Urease activity was optimum at a urea concentration of 0.3 M. The comparisonÂ Cu, and PbÂ concentration determination using the urease inhibitory activity and AAS methods showed no significant difference at 95% confidence level. This research showed that urease ofÂ D. zibethinusÂ L. seed could be used to determine Cu and Pb's concentration based on its inhibiting activity.

Computational Study of Scorpion Venom (Lychas Mucronatus) Activity as Antimicrobial Peptides (AMPs) to the SARS-CoV-2 Main Protease for the Future Coronavirus Disease (COVID-19) Inhibitors Taufik Muhammad Fakih
Molekul Vol 16, No 2 (2021)
Publisher : Universitas Jenderal Soedirman

The 2019 coronavirus pandemic disease (COVID-19) is still declared a global pandemic by the World Health Organization (WHO). Therefore, an effort that is considered effective in finding therapeutic agents is needed to prevent the spread of COVID-19 infection. One of the steps that can be chosen is by utilizing antimicrobial peptides (AMPs) from animal venom by targeting the specific receptor of SARS-CoV-2, namely the main protease (Mpro). Through this research, a computational approach will be conducted to predict antiviral activity, including protein-peptide docking using PatchDock algorithm, to identify, evaluate, and explore the affinity and molecular interactions of four types of antimicrobial peptides (AMPs), such as Mucroporin, Mucroporin-M1, Mucroporin-S1, and Mucroporin-S2 derived from scorpion venom (Lychas mucronatus) against main protease (Mpro) SARS-CoV-2. These results were then confirmed using protein-peptide interaction dynamics simulations for 50 ns using Gromacs 2016 to observe the molecular stability to the binding site of SARS-CoV-2 Mpro. Based on protein-peptide docking simulations, it was proven that the Mucroporin S-1 peptides have a good affinity against the active site area of SARS-CoV-2 Mpro, with an ACE score of −779.56 kJ/mol. Interestingly, Mucroporin-S1 was able to maintain the stability of its interactions based on the results of RMSD, RMSF, and MM/PBSA binding free energy calculations. The results of the computational approach predict that the Mucroporin-S1 peptide is expected to be useful for further research in the development of new antiviral-based AMPs for the COVID-19 infectious disease.

Frontmatter (Front Cover, Editorial Team, Preface and Table of Contents) Amin Fatoni
Molekul Vol 16, No 2 (2021)
Publisher : Universitas Jenderal Soedirman

Frontmatter (Front Cover, Editorial Team, Preface and Table of Contents)

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Amin Fatoni

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Home Page

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Editorial Team

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Contact Name Amin Fatoni

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Journal Mail Official j.molekul@gmail.com

Editorial Address Jl. Dr. Soeparno No.61 Karangwangkal, Purwokerto, Jawa Tengah 53

Location Kab. banyumas, Jawa tengah INDONESIA

Abstract

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Abstract

Contact Name
Amin Fatoni

Contact Email
aminfatoni@unsoed.ac.id

Phone
-

Journal Mail Official
j.molekul@gmail.com

Editorial Address
Jl. Dr. Soeparno No.61 Karangwangkal, Purwokerto, Jawa Tengah 53

Location
Kab. banyumas,

Jawa tengah

INDONESIA